Vivek verma american radium society12/2/2023 ![]() Overall survival was shorter with hypofractionated radiotherapy in the early concurrent chemotherapy subset (15.8 vs. On PSM (N=292), median overall survival was similar between standard radiotherapy vs. Multivariable analysis on the whole cohort yielded comparable overall survival (HR for hypofractionated radiotherapy 1.09, CI: 0.90–1.32, P=0.37). Results: Seven thousand and one hundred forty-three patients were included: 97.9% received standard radiotherapy and 2.1% hypofractionated radiotherapy. Early concurrent chemotherapy consisted of radiotherapy and chemotherapy initiated within 30 days of each other. Propensity score matching (PSM) was performed as a sensitivity analysis. Kaplan-Meier estimator, log-rank test, and multivariable Cox regression were used to evaluate overall survival. Patient characteristics were assessed with univariable and multivariable logistic regression. Methods: We included patients in the National Cancer Database with unresected primary stage II–III small cell lung cancer in 2008–2016 who underwent chemotherapy within six months of either hypofractionated radiotherapy (40–45 Gy/15 fractions) or standard radiotherapy (45 Gy/30 fractions or 60–70 Gy/30–35 fractions) in this retrospective cohort study. We examined practice patterns and overall survival with definitive hypofractionated radiotherapy and chemotherapy vs. Anderson Cancer Center, Houston, TX, USA ĥ Division of Radiation Oncology, University of Vermont Larner College of Medicine, Burlington, VT, USA Ħ Department of Pathology, Yale School of Medicine, New Haven, CT, USAĬontributions: (I) Conception and design: All authors (II) Administrative support: HS Park (III) Provision of study materials or patients: HS Park (IV) Collection and assembly of data: HS Park (V) Data analysis and interpretation: NA Saeed, L Jin, AW Sasse, HS Park (VI) Manuscript writing: All authors (VII) Final approval of manuscript: All authors.īackground: Hypofractionated radiotherapy in locally advanced limited-stage small cell lung cancer is preferred in many Western countries but not used regularly in the United States. Park 1ġ Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA Ģ Department of Surgery, Yale School of Medicine, New Haven, CT, USA ģ Department of Radiation Oncology, City of Hope, Duarte, CA, USA Ĥ Department of Radiation Oncology, University of Texas M.D. Sasse 1, Arya Amini 3, Vivek Verma 4, Nataniel H. Interviews with Outstanding Guest Editors.Policy of Dealing with Allegations of Research Misconduct. ![]() Policy of Screening for Plagiarism Process.
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